Cluster models in cellular level electron dose calculations.
Identifieur interne : 003C82 ( Main/Exploration ); précédent : 003C81; suivant : 003C83Cluster models in cellular level electron dose calculations.
Auteurs : RBID : pubmed:10380829English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Indium Radioisotopes.
- radiation effects : Cells.
- Absorption, Cluster Analysis, Electrons, Humans, Monte Carlo Method, Radioimmunotherapy, Radiometry, Tumor Cells, Cultured.
Abstract
A program for calculating absorbed dose was developed for radioimmunotherapy (RIT) purposes. It was used to determine the difference in the therapeutic effect of (111)In electrons when using a close-packed cubic geometry and a cell cluster model developed in this project. Our cluster model piles the cells individually. The cells were modelled as spheres of diameters of 12 (tumour) and 30 (healthy) microm. Both models were used to generate clusters with spherical tumours inside healthy tissue. The program uses Monte Carlo-based dose kernels. The radiation spectra were calculated from the Auger and x-ray transition strengths and fluorescence yields of (111)In. The results show the importance of the cluster model in cellular level dose calculations. Near the tumour/healthy tissue interface in particular, the doses differ because of geometrical differences. In the case of a small cluster with tumour and total diameters of 30 and 150 microm, the ratio of the therapeutic effects is 20.
PubMed: 10380829
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Juha.Lampinen@Helsinki.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Physics, University of Helsinki, and Helsinki University Central Hospital</wicri:regionArea></affiliation></author><author><name sortKey="V Lim Ki, P J" uniqKey="V Lim Ki P">P J Välimäki</name></author><author><name sortKey="Kuronen, A A" uniqKey="Kuronen A">A A Kuronen</name></author><author><name sortKey="Stepanek, J" uniqKey="Stepanek J">J Stepanek</name></author><author><name sortKey="Savolainen, S E" uniqKey="Savolainen S">S E Savolainen</name></author></titleStmt><publicationStmt><date when="1999">1999</date><idno type="RBID">pubmed:10380829</idno><idno type="pmid">10380829</idno><idno type="wicri:Area/Main/Corpus">003E65</idno><idno type="wicri:Area/Main/Curation">003E65</idno><idno type="wicri:Area/Main/Exploration">003C82</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Absorption</term><term>Cells (radiation effects)</term><term>Cluster Analysis</term><term>Electrons</term><term>Humans</term><term>Indium Radioisotopes (therapeutic use)</term><term>Monte Carlo Method</term><term>Radioimmunotherapy</term><term>Radiometry</term><term>Tumor Cells, Cultured</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Indium Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Absorption</term><term>Cluster Analysis</term><term>Electrons</term><term>Humans</term><term>Monte Carlo Method</term><term>Radioimmunotherapy</term><term>Radiometry</term><term>Tumor Cells, Cultured</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A program for calculating absorbed dose was developed for radioimmunotherapy (RIT) purposes. It was used to determine the difference in the therapeutic effect of (111)In electrons when using a close-packed cubic geometry and a cell cluster model developed in this project. Our cluster model piles the cells individually. The cells were modelled as spheres of diameters of 12 (tumour) and 30 (healthy) microm. Both models were used to generate clusters with spherical tumours inside healthy tissue. The program uses Monte Carlo-based dose kernels. The radiation spectra were calculated from the Auger and x-ray transition strengths and fluorescence yields of (111)In. The results show the importance of the cluster model in cellular level dose calculations. Near the tumour/healthy tissue interface in particular, the doses differ because of geometrical differences. In the case of a small cluster with tumour and total diameters of 30 and 150 microm, the ratio of the therapeutic effects is 20.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">10380829</PMID><DateCreated><Year>1999</Year><Month>07</Month><Day>07</Day></DateCreated><DateCompleted><Year>1999</Year><Month>07</Month><Day>07</Day></DateCompleted><DateRevised><Year>2009</Year><Month>05</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0284-186X</ISSN><JournalIssue CitedMedium="Print"><Volume>38</Volume><Issue>3</Issue><PubDate><Year>1999</Year></PubDate></JournalIssue><Title>Acta oncologica (Stockholm, Sweden)</Title><ISOAbbreviation>Acta Oncol</ISOAbbreviation></Journal><ArticleTitle>Cluster models in cellular level electron dose calculations.</ArticleTitle><Pagination><MedlinePgn>367-72</MedlinePgn></Pagination><Abstract><AbstractText>A program for calculating absorbed dose was developed for radioimmunotherapy (RIT) purposes. It was used to determine the difference in the therapeutic effect of (111)In electrons when using a close-packed cubic geometry and a cell cluster model developed in this project. Our cluster model piles the cells individually. The cells were modelled as spheres of diameters of 12 (tumour) and 30 (healthy) microm. Both models were used to generate clusters with spherical tumours inside healthy tissue. The program uses Monte Carlo-based dose kernels. The radiation spectra were calculated from the Auger and x-ray transition strengths and fluorescence yields of (111)In. The results show the importance of the cluster model in cellular level dose calculations. Near the tumour/healthy tissue interface in particular, the doses differ because of geometrical differences. In the case of a small cluster with tumour and total diameters of 30 and 150 microm, the ratio of the therapeutic effects is 20.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lampinen</LastName><ForeName>J S</ForeName><Initials>JS</Initials><Affiliation>Department of Physics, University of Helsinki, and Helsinki University Central Hospital, Finland. Juha.Lampinen@Helsinki.fi</Affiliation></Author><Author ValidYN="Y"><LastName>Välimäki</LastName><ForeName>P J</ForeName><Initials>PJ</Initials></Author><Author ValidYN="Y"><LastName>Kuronen</LastName><ForeName>A A</ForeName><Initials>AA</Initials></Author><Author ValidYN="Y"><LastName>Stepanek</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Savolainen</LastName><ForeName>S E</ForeName><Initials>SE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>NORWAY</Country><MedlineTA>Acta Oncol</MedlineTA><NlmUniqueID>8709065</NlmUniqueID><ISSNLinking>0284-186X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Absorption</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cells</DescriptorName><QualifierName MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cluster Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Electrons</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Monte Carlo Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Radioimmunotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Radiometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tumor Cells, Cultured</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>6</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>6</Month><Day>25</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>6</Month><Day>25</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10380829</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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